サトイ ソウヘイ   SATOI SOUHEI
  里井 壯平
   所属   関西医科大学  胆膵外科学講座
   職種   教授
論文種別 原著(症例報告除く)
言語種別 英語
査読の有無 査読あり
表題 Increased extra domain-A containing fibronectin and hepatic dysfunction during septic response: An in vivo and in vitro study
掲載誌名 正式名:Shock
略  称:Shock
ISSNコード:10732322
巻・号・頁 13(6),pp.492-496
著者・共著者 Satoi S, Kitade H, Hiramatsu Y, A-Hon K, Takahashi H, Sekiguchi K, Uehara M, Oda M, Yanagimoto Y, Miyashita K, Sakashita E, Kamiyama Y
担当区分 筆頭著者
発行年月 2000/06
概要 A massive inflammatory reaction resulting from systemic cytokine release is the common pathway underlying sepsis or multiple organ dysfunction. The role of extra domain sequence A-containing fibronectin (EDA+FN) formation during the septic response is not known. The present study investigates the role of EDA+FN during the septic response under in vitro and in vivo conditions. The direct effects of interleukin-1, interleukin-6, and tumor necrosis factor-α on EDA+FN production were evaluated in primary cultured human hepatocytes and fibroblasts. Serial plasma EDA+FN levels were measured using an enzyme-linked immunosorbent assay in 24 patients who developed postoperative sepsis following general abdominal surgery of which there were 17 survivors and 7 non-survivors. EDA+FN secretion was significantly increased in cultured hepatocytes but not fibroblasts at 24 and 48 h following exposure to IL-1 compared to controls. In the clinical setting plasma EDA+FN levels in non-survivors were significantly higher than in survivors. Moreover, the EDA+FN levels were correlated closely with liver function tests. EDA+FN levels may represent a specific marker of vascular injury or systemic inflammatory response syndrome that is associated with an adverse clinical outcome.
文献番号 10847638