コバヤカワ　コウ   KOBAYAKAWA KOU   小早川　高    所属   関西医科大学  附属生命医学研究所侵襲反応制御部門    職種   研究所教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	Thiazoline-related innate fear stimuli orchestratehypothermia　and anti-hypoxia via sensory TRPA1activation
掲載誌名	正式名：Nature communications 略　 称：Nat Commun ISSNコード：20411723
巻・号・頁	12(1),pp.2074
著者・共著者	Tomohiko Matsuo, Tomoko Isosaka, Yuichiro Hayashi, Lijun Tang1 Akihiro Doi1, Aiko Yasuda, Mikio Hayashi, Chia-Ying Lee, Liqin Cao, Natsumaro Kutsuna5, Sachihiro Matsunaga, Takeshi Matsuda, Ikuko Yao, Mitsuyoshi Setou8, Dai Kanagawa, Koichiro Higasa, Masahito Ikawa, Qinghua Liu, Reiko Kobayakawa & Ko Kobayakawa
発行年月	2021/04
概要	Thiazoline-related innate fear-eliciting compounds (tFOs) orchestrate hypothermia, hypometabolism, and anti-hypoxia, which enable survival in lethal hypoxic conditions. Here, we show that most of these effects are severely attenuated in transient receptor potential ankyrin 1 (Trpa1) knockout mice. TFO-induced hypothermia involves the Trpa1-mediated trigeminal/vagal pathways and non-Trpa1 olfactory pathway. TFOs activate Trpa1-positive sensory pathways projecting from trigeminal and vagal ganglia to the spinal trigeminal nucleus (Sp5) and nucleus of the solitary tract (NTS), and their artificial activation induces hypothermia. TFO presentation activates the NTS-Parabrachial nucleus pathway to induce hypothermia and hypometabolism; this activation was suppressed in Trpa1 knockout mice. TRPA1 activation is insufficient to trigger tFO-mediated anti-hypoxic effects; Sp5/NTS activation is also necessary. Accordingly, we find a novel molecule that enables mice to survive in a lethal hypoxic condition ten times longer than known tFOs. Combinations of appropriate tFOs and TRPA1 command intrinsic physiological responses relevant to survival fate.
DOI	10.1038/s41467-021-22205-0
PMID	33824316