イノウエ　アキトシ   INOUE AKITOSHI   井上　明俊    所属   関西医科大学  医化学講座    職種   助教
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	Forgetting in C. Elegans Is Accelerated by Neuronal Communication via the TIR-1/JNK-1 Pathway
掲載誌名	正式名：Cell reports 略　 称：Cell Rep ISSNコード：22111247
巻・号・頁	28(3),pp.808-819
著者・共著者	Inoue A., Sawatari E., Hisamoto N., Kitazono T., Teramoto T., Fujiwara M., Matsumoto K., Ishihara T.
担当区分	筆頭著者
発行年月	2013/03
概要	The control of memory retention is important for proper responses to constantly changing environments, but the regulatory mechanisms underlying forgetting have not been fully elucidated. Our genetic analyses in C. elegans revealed that mutants of the TIR-1/JNK-1 pathway exhibited prolonged retention of olfactory adaptation and salt chemotaxis learning. In olfactory adaptation, conditioning induces attenuation of odor-evoked Ca(2+) responses in olfactory neurons, and this attenuation is prolonged in the TIR-1/JNK-1-pathway mutant animals. We also found that a pair of neurons in which the pathway functions is required for the acceleration of forgetting, but not for sensation or adaptation, in wild-type animals. In addition, the neurosecretion from these cells is important for the acceleration of forgetting. Therefore, we propose that these neurons accelerate forgetting through the TIR-1/JNK-1 pathway by sending signals that directly or indirectly stimulate forgetting.