コバヤカワ レイコ   KOBAYAKAWA REIKO
  小早川 令子
   所属   関西医科大学  附属生命医学研究所神経機能部門
   職種   研究所教授
論文種別 原著(症例報告除く)
言語種別 英語
査読の有無 その他(不明)
表題 Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice
掲載誌名 正式名:Nature communications
略  称:Nat Commun
ISSNコード:20411723
巻・号・頁 12(1),pp.2648
著者・共著者 Can Liu, Chia-Ying Lee, Greg Asher, Liqin Cao, Yuka Terakoshi, Peng Cao, Reiko Kobayakawa, Ko Kobayakawa, Katsuyasu Sakurai& Qinghua Liu
発行年月 2021/05
概要 The neural mechanisms of fear-associated thermoregulation remain unclear. Innate fear odor 2-methyl-2-thiazoline (2MT) elicits rapid hypothermia and elevated tail temperature, indicative of vasodilation-induced heat dissipation, in wild-type mice, but not in mice lacking Trpa1-the chemosensor for 2MT. Here we report that Trpa1-/- mice show diminished 2MT-evoked c-fos expression in the posterior subthalamic nucleus (PSTh), external lateral parabrachial subnucleus (PBel) and nucleus of the solitary tract (NTS). Whereas tetanus toxin light chain-mediated inactivation of NTS-projecting PSTh neurons suppress, optogenetic activation of direct PSTh-rostral NTS pathway induces hypothermia and tail vasodilation. Furthermore, selective opto-stimulation of 2MT-activated, PSTh-projecting PBel neurons by capturing activated neuronal ensembles (CANE) causes hypothermia. Conversely, chemogenetic suppression of vGlut2+ neurons in PBel or PSTh, or PSTh-projecting PBel neurons attenuates 2MT-evoked hypothermia and tail vasodilation. These studies identify PSTh as a major thermoregulatory hub that connects PBel to NTS to mediate 2MT-evoked innate fear-associated hypothermia and tail vasodilation.
DOI 10.1038/s41467-021-22914-6
PMID 33976193