ハットリ　フミユキ   HATTORI FUMIYUKI   服部　文幸    所属   関西医科大学  iPS・幹細胞再生医学講座    職種   研究教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Distinct iPS Cells Show Different Cardiac Differentiation Efficiency.
掲載誌名	正式名：Stem cells international 略　 称：Stem Cells Int ISSNコード：1687966X
巻・号・頁	2013,pp.659739
著者・共著者	Ohno Yohei, Yuasa Shinsuke, Egashira Toru, Seki Tomohisa, Hashimoto Hisayuki, Tohyama Shugo, Saito Yuki, Kunitomi Akira, Shimoji Kenichiro, Onizuka Takeshi, Kageyama Toshimi, Yae Kojiro, Tanaka Tomofumi, Kaneda Ruri, Hattori Fumiyuki, Murata Mitsushige, Kimura Kensuke, Fukuda Keiichi
発行年月	2013
概要	Patient-specific induced pluripotent stem (iPS) cells can be generated by introducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells. This opens up new possibilities for cell transplantation-based regenerative medicine by overcoming the ethical issues and immunological problems associated with ES cells. Despite the development of various methods for the generation of iPS cells that have resulted in increased efficiency, safety, and general versatility, it remains unknown which types of iPS cells are suitable for clinical use. Therefore, the aims of the present study were to assess (1) the differentiation potential, time course, and efficiency of different types of iPS cell lines to differentiate into cardiomyocytes in vitro and (2) the properties of the iPS cell-derived cardiomyocytes. We found that high-quality iPS cells exhibited better cardiomyocyte differentiation in terms of the time course and efficiency of differentiation than low-quality iPS cells, which hardly ever differentiated into cardiomyocytes. Because of the different properties of the various iPS cell lines such as cardiac differentiation efficiency and potential safety hazards, newly established iPS cell lines must be characterized prior to their use in cardiac regenerative medicine.
DOI	10.1155/2013/659739
PMID	24367382