ハットリ　フミユキ   HATTORI FUMIYUKI   服部　文幸    所属   関西医科大学  iPS・幹細胞再生医学講座    職種   研究教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Strategies for replacing myocytes with induced pluripotent stem in clinical protocols.
掲載誌名	正式名：Transplantation reviews (Orlando, Fla.) 略　 称：Transplant Rev (Orlando) ISSNコード：155798160955470X
巻・号・頁	26(3),pp.223-32
著者・共著者	Hattori Fumiyuki, Fukuda Keiichi
発行年月	2012/07
概要	Induced pluripotent stem (iPS) cells can be established via forced epigenetic reprogramming of various somatic cells and selection based on given criteria. Human iPS cells are preferred for clinical applications because they present fewer ethical concerns than embryonic stem cells. However, technical issues of stability and safety must be fully validated before clinical use. Moreover, heart regenerative therapies would require approximately 10(9) cardiomyocytes per person, necessitating the following technical considerations: (1) genetically and epigenetically stable scaling up of the iPS cells, (2) efficient and reproducible differentiation, and (3) highly reliable cell purification. Furthermore, (4) strategies for efficient iPS transplantation, rapid maturation, and functional integration of grafted cardiomyocytes into the host myocardium are critical unmet technologies. Herein, we discuss current progress and unmet problems for the realization of heart regenerative therapy.
DOI	10.1016/j.trre.2011.09.003
PMID	22172453