ハットリ　フミユキ   HATTORI FUMIYUKI   服部　文幸    所属   関西医科大学  iPS・幹細胞再生医学講座    職種   研究教授
論文種別	その他
言語種別	英語
査読の有無	その他(不明)
表題	Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells.
掲載誌名	正式名：Nature biotechnology 略　 称：Nat Biotechnol ISSNコード：1087015610870156
巻・号・頁	23(5),pp.607-11
著者・共著者	Yuasa Shinsuke, Itabashi Yuji, Koshimizu Uichi, Tanaka Tomofumi, Sugimura Keijiro, Kinoshita Masayoshi, Hattori Fumiyuki, Fukami Shin-ichi, Shimazaki Takuya, Ogawa Satoshi, Okano Hideyuki, Fukuda Keiichi
発行年月	2005/05
概要	Embryonic stem (ES) cells are a promising source of cardiomyocytes, but clinical application of ES cells has been hindered by the lack of reliable selective differentiation methods. Differentiation into any lineage is partly dependent on the regulatory mechanisms of normal early development. Although several signals, including bone morphogenetic protein (BMP), Wnt and FGF, are involved in heart development, scarce evidence is available about the exact signals that mediate cardiomyocyte differentiation. While investigating the involvement of BMP signaling in early heart formation in the mouse, we found that the BMP antagonist Noggin is transiently but strongly expressed in the heart-forming region during gastrulation and acts at the level of induction of mesendoderm to establish conditions conducive to cardiogenesis. We applied this finding to develop an effective protocol for obtaining cardiomyocytes from mouse ES cells by inhibition of BMP signaling.
DOI	10.1038/nbt1093
PMID	15867910