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マツダ タダシ
MATSUDA TADASHI 松田 公志 所属 関西医科大学 附属枚方病院専任教員 職種 病院長 |
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| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | その他(不明) |
| 表題 | Add-on anticholinergic therapy for residual nocturia in patients with lower urinary tract symptoms receiving α1-blocker treatment: a multi-centre, prospective, randomised study |
| 掲載誌名 | 正式名：World Journal of Urology 略 称：World J Urol ISSNコード：0724-4983 |
| 巻・号・頁 | 33(5),pp.659-667 |
| 著者・共著者 | Yokoyama O, Tsujimura A, Akino H, Segawa N, Tamada S, Oguchi N, Kitagawa Y, Tsuji H, Watanabe A, Inamoto T, Shimizu N, Fujiuchi Y, Katsuoka Y, Azuma H, Matsuda T, Namiki M, Uemura H, Okuyama A, Nonomura N, Fuse H, Nakatani T |
| 発行年月 | 2015/05 |
| 概要 | Purpose
To evaluate the efficacy and safety of imidafenacin (IM), a novel short half-life anticholinergic, as add-on therapy for male LUTS with nocturia and nocturnal polyuria. Materials and methods This multicenter, prospective, randomized, open-labelled study was conducted and involved men who had frequency, urgency, and nocturia despite receiving a stable dose of α1-blocker for ≥1 month. Subjects were randomised to control (α1-blocker alone), IM twice/day (α1-blocker +0.1 mg imidafenacin twice daily), or IM nightly (α1-blocker plus 0.1 mg imidafenacin nightly) group; the treatment period was 8 weeks. Primary endpoints included improvements in night-time frequency and Nocturia Quality of Life Questionnaire (N-QOL) scores. Secondary endpoints included changes from the baseline in frequency volume chart variables, and post-void residual volume. Results and limitations Compared with the controls, IM twice/day and IM nightly patients had a significantly lower night-time frequency (changes from baseline: 0.1 ± 0.8 in control, −0.6 ± 0.9 in IM twice/day, and −0.4 ± 1.0 in IM nightly, p = 0.5227, 0.0006 and 0.0143, respectively). The hours of undisturbed sleep and N-QOL score were significantly improved in IM twice/day group, though not IM nightly group. Nocturnal urine volume was significantly reduced in IM nightly group, although total urine volume remained unchanged. Conclusions A short half-life anticholinergic is suggested to be safe and effective as an add-on therapy for residual nocturia in patients with male LUTS receiving α1-blocker treatment. Anticholinergic administration nightly could reduce the nocturnal urine volume. |
| DOI | 10.1007/s00345-014-1399-x |
| 文献番号 | 25224929 |
| PMID | 25224929 |