マツダ　タダシ   MATSUDA TADASHI   松田　公志    所属   関西医科大学  附属枚方病院専任教員    職種   病院長
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	A novel risk stratification model, involving preoperative lymphocyte-monocyte ratio and standard pathological factors, for overall survival in patients with bladder cancer undergoing radical cystectomy
掲載誌名	正式名：Japanese Journal of Clinical Oncology 略　 称：Jpn J Clin Oncol.
巻・号・頁	45(12),pp.1162-1167
著者・共著者	Yoshida T, Kinoshita H, Yoshida K, Yanishi M, Inui H, Komai Y, Sugi M, Inoue T, Murota T, Matsuda 1
担当区分	最終著者
発行年月	2015/12
概要	To evaluate the ability of preoperative lymphocyte-monocyte ratio to predict prognosis and determine post-operative risk stratification in patients with bladder cancer undergoing radical cystectomy. METHODS: A retrospective review of the 210 patients who had undergone radical cystectomy for bladder cancer from 2006 to 2013 identified 181 patients with sufficient data to evaluate the prognostic significance of the lymphocyte-monocyte ratio. Overall survival was assessed by the Kaplan-Meier method. The association of clinicopathological findings with overall survival was evaluated by a multivariate Cox proportional model, and a novel risk stratification model to predict prognosis was established. RESULTS: Median follow-up after radical cystectomy was 6.0 years. The 5-year overall survival rate was significantly lower for patients with low than high lymphocyte-monocyte ratio (27.6 vs 80.7%, P < 0.001). Multivariable analyses showed that pT ≥2, pN ≥1, positive margins and low lymphocyte-monocyte ratio were independent predictors of overall survival. A post-operative risk stratification model using these factors showed significant differences among the three subgroups (low, intermediate and high risk) with a concordance index of 0.84. The 5-year overall survival rates in patients at low, intermediate and high risk were 85.4, 45.5 and 0%, respectively (P < 0.001). CONCLUSIONS: Preoperative lymphocyte-monocyte ratio, pathological tumor and lymph node stage and positive margins are significantly associated with overall survival in patients who have undergone radical cystectomy for bladder cancer.
DOI	10.1093/jjco/hyv146
文献番号	PMID: 26423342
PMID	26423342