ツジ　シヨウジ   TSUJI SHOJI   辻　章志    所属   関西医科大学  小児科学講座    職種   准教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Two Cases of Autoimmune Neutropenia Possibly Induced by β-lactam Antibiotics in Infants
掲載誌名	正式名：Journal of pediatric hematology/oncology 略　 称：J Pediatr Hematol Oncol ISSNコード：10774114
巻・号・頁	22(6),pp.533-538
著者・共著者	Taniuchi S, Masuda M, Yamamoto A, Hasui M, Tsuji S, Takahashi H and Kobayashi Y
発行年月	2000/11
概要	This report describes two infants who had neutropenia develop after treatment with [beta]-lactam antibiotics. The first patient, a 9-month-old girl, was administered flomoxef (FMOX); the second patient, a 14-month-old boy, was administered cefotiam (CTM). Both infants were found to have neutropenia 4 to 5 days after they were placed on respective antibiotics, and neutropenia had persisted despite antibiotics withdrawal for 1 to 3 months. Drug-induced lymphocyte stimulation test (DLST), granulocyte-bound antibodies, serum granulocyte antibodies, and immunoblotting analysis indicated that [beta]-lactam antibiotics possibly triggered production of granulocyte autoantibody with resultant autoimmune neutropenia.