サトイ　ソウヘイ   SATOI SOUHEI   里井　壯平    所属   関西医科大学  胆膵外科学講座    職種   教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	Increased extra domain-A containing fibronectin and hepatic dysfunction during septic response: An in vivo and in vitro study
掲載誌名	正式名：Shock 略　 称：Shock ISSNコード：10732322
巻・号・頁	13(6),pp.492-496
著者・共著者	Satoi S, Kitade H, Hiramatsu Y, A-Hon K, Takahashi H, Sekiguchi K, Uehara M, Oda M, Yanagimoto Y, Miyashita K, Sakashita E, Kamiyama Y
担当区分	筆頭著者
発行年月	2000/06
概要	A massive inflammatory reaction resulting from systemic cytokine release is the common pathway underlying sepsis or multiple organ dysfunction. The role of extra domain sequence A-containing fibronectin (EDA+FN) formation during the septic response is not known. The present study investigates the role of EDA+FN during the septic response under in vitro and in vivo conditions. The direct effects of interleukin-1, interleukin-6, and tumor necrosis factor-α on EDA+FN production were evaluated in primary cultured human hepatocytes and fibroblasts. Serial plasma EDA+FN levels were measured using an enzyme-linked immunosorbent assay in 24 patients who developed postoperative sepsis following general abdominal surgery of which there were 17 survivors and 7 non-survivors. EDA+FN secretion was significantly increased in cultured hepatocytes but not fibroblasts at 24 and 48 h following exposure to IL-1 compared to controls. In the clinical setting plasma EDA+FN levels in non-survivors were significantly higher than in survivors. Moreover, the EDA+FN levels were correlated closely with liver function tests. EDA+FN levels may represent a specific marker of vascular injury or systemic inflammatory response syndrome that is associated with an adverse clinical outcome.
文献番号	10847638