キタデ　ヒロアキ   KITADE HIROAKI   北出　浩章    所属   関西医科大学  胆膵外科学講座    職種   准教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis
掲載誌名	正式名：Clinical and experimental pharmacology & physiology 略　 称：Clin Exp Pharmacol Physiol ISSNコード：03051870/14401681
巻・号・頁	27(3),pp.197-201
著者・共著者	Satoi S, Kamiyama Y, Kitade H, A-Hon K, Takahashi K, Tu W, Inoue T, Takahashi H
発行年月	2000/03
概要	1. Although hepatic function is well known to deteriorate following bacterial infection, the underlying mechanisms remain poorly understood. We have previously reported that nitric oxide (NO) radical leads to a decrease in the ketone body ratio (KBR) and in ATP content due to the inhibition of mitochondrial electron transport in primary cultured rat hepatocytes. 2. To evaluate the effects of NO radical on the liver in patients with postoperative sepsis, we analysed both the stable end-product of nitric oxide radical (NOx) as well as the arterial KBR (AKBR), which reflects liver tissue NAD+/NADH. 3. Twenty patients who had undergone general abdominal surgery and who developed postoperative sepsis were divided into two groups: (i) surviving; and (ii) non-surviving. Blood samples were collected before the development of postoperative sepsis and every 3 days until the patient either died or was discharged from hospital. 4. Plasma NOx levels in seven patients who subsequently died became progressively higher than those in the 13 surviving patients over the clinical course of postoperative sepsis. 5. In the non-surviving group, the AKBR was significantly lower than in surviving patients, indicating impaired hepatic function. In contrast, plasma NOx levels in non-surviving patients were significantly higher than in surviving patients. 6. Decreases in AKBR to levels below 0.7 in non-surviving patients followed high NOx levels. Moreover, plasma NOx levels were closely correlated with the AKBR, indicating that NO radical is associated with mitochondrial dysfunction in the liver. 7. It is likely that the overproduction of NO radical plays an important role in causing fatal metabolic disorders in patients with postoperative sepsis.
DOI	10.1046/j.1440-1681.2000.03228.x
文献番号	10744347