マツウラ　トオル   MATSUURA TORU   松浦　徹    所属   関西医科大学  病理学講座    職種   講師
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate signals.
掲載誌名	正式名：Science Signaling 略　 称：Sci Signal ISSNコード：19379145
掲載区分	国外
巻・号・頁	2(79),pp.ra34
著者・共著者	Hiroki Akiyama, Toru Matsu-ura, Katsuhiko Mikoshiba, Hiroyuki Kamiguchi
担当区分	2nd著者
発行年月	2009/06
概要	Inositol 1,4,5-trisphosphate (IP(3)) is generally viewed as a global messenger that increases cytosolic calcium ion (Ca(2+)) concentration. However, the spatiotemporal dynamics of IP(3) and the functional significance of localized IP(3) production in cell polarity remain largely unknown. Here, we demonstrate the critical role of spatially restricted IP(3) signals in axon guidance. We found that IP(3) and ensuing Ca(2+) signals were produced asymmetrically across growth cones exposed to an extracellular gradient of nerve growth factor (NGF) and mediated growth cone turning responses to NGF. Moreover, photolysis-induced production of IP(3) on one side of a growth cone was sufficient to initiate growth cone turning toward the side with the higher concentration of IP(3). Thus, locally produced IP(3) encodes spatial information that polarizes the growth cone for guided migration.