ノナカ　マサヒロ   NONAKA MASAHIRO   埜中　正博    所属   関西医科大学  脳神経外科学講座    職種   教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	A case of pilocytic astrocytoma requiring tumor resection during pregnancy.
掲載誌名	正式名：Molecular and clinical oncology 略　 称：Mol Clin Oncol ISSNコード：2049945020499450
巻・号・頁	4(4),pp.567-570
著者・共著者	Umehara Toru, Okita Yoshiko, Nonaka Masahiro, Kanemura Yonehiro, Kodama Yoshinori, Mano Masayuki, Nakajima Shin, Fujinaka Toshiyuki
発行年月	2016/04
概要	Low-grade glioma (LGG) is often encountered in relatively young individuals, including women of childbearing age. Notably, case series describing pregnant women with LGG have been reported in the literature. The present study reported a case of pilocytic astrocytoma (PA) requiring tumor resection during pregnancy. The patient had a history of γ-knife radiotherapy for a brainstem tumor 17 years previously. The histological diagnosis was unclear. The tumor had remained stable following radiosurgery for 17 years, including during her first pregnancy. However, rapid tumor growth around the fourth ventricle occurred at week 25 of her second pregnancy. Therefore, an urgent tumor resection was performed despite the pregnancy. Partial resection was performed since the tumor had infiltrated the brainstem. The histological diagnosis was PA. The residual tumor volume decreased gradually following the delivery. Immunostaining of the tumor for the expression of progesterone receptor revealed focal staining. It is possible that reproductive factors, including specific hormonal changes during pregnancy, affected the tumor growth. The present study described this rare case of PA, which exhibited rapid growth and required urgent surgery during pregnancy.
DOI	10.3892/mco.2016.773
PMID	27073664