ムラタ　ヒロミ   MURATA HIROMI   村田　紘未    所属   関西医科大学  産科学・婦人科学講座    職種   講師
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Immune Tolerance of the Human Decidua
掲載誌名	正式名：Journal of clinical medicine 略　 称：J Clin Med ISSNコード：20770383
掲載区分	国外
巻・号・頁	10(2),pp.351
著者・共著者	Murata H, Tanaka S, Okada H
担当区分	筆頭著者
発行年月	2021/01
概要	The endometrium is necessary for implantation, complete development of the placenta, and a successful pregnancy. The endometrium undergoes repeated cycles of proliferation, decidualization (differentiation), and shedding during each menstrual cycle. The endometrium-including stromal, epithelial, vascular endothelial, and immune cells-is both functionally and morphologically altered in response to progesterone, causing changes in the number and types of immune cells. Immune cells make up half of the total number of endometrial cells during implantation and menstruation. Surprisingly, immune tolerant cells in the endometrium (uterine natural killer cells, T cells, and macrophages) have two conflicting functions: to protect the body by eliminating pathogenic microorganisms and other pathogens and to foster immunological change to tolerate the embryo during pregnancy. One of the key molecules involved in this control is the cytokine interleukin-15 (IL-15), which is secreted by endometrial stromal cells. Recently, it has been reported that IL-15 is directly regulated by the transcription factor heart- and neural crest derivatives-expressed protein 2 in endometrial stromal cells. In this review, we outline the significance of the endometrium and immune cell population during menstruation and early pregnancy and describe the factors involved in immune tolerance and their involvement in the establishment and maintenance of pregnancy.
DOI	10.3390/jcm10020351
PMID	33477602