コバヤカワ　コウ   KOBAYAKAWA KOU   小早川　高    所属   関西医科大学  附属生命医学研究所侵襲反応制御部門    職種   研究所教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors
掲載誌名	正式名：communications BIOLOGY
掲載区分	国外
巻・号・頁	4(1),pp.101
著者・共著者	Tomohiko Matsuo, Tomoko Isosaka,　 Lijun Tang, Tomoyoshi Soga,　 Reiko Kobayakawa, Ko Kobayakawa
担当区分	最終著者,責任著者
発行年月	2021/01
概要	Innate fear intimately connects to the life preservation in crises, although this relationships is not fully understood. Here, we report that presentation of a supernormal innate fear inducer 2-methyl-2-thiazoline (2MT), but not learned fear stimuli, induced robust systemic hypothermia/hypometabolism and suppressed aerobic metabolism via phosphorylation of pyruvate dehydrogenase, thereby enabling long-term survival in a lethal hypoxic environment. These responses exerted potent therapeutic effects in cutaneous and cerebral ischemia/reperfusion injury models. In contrast to hibernation, 2MT stimulation accelerated glucose uptake in the brain and suppressed oxygen saturation in the blood. Whole-brain mapping and chemogenetic activation revealed that the sensory representation of 2MT orchestrates physiological responses via brain stem Sp5/NST to midbrain PBN pathway. 2MT, as a supernormal stimulus of innate fear, induced exaggerated, latent life-protective effects in mice. If this system is preserved in humans, it may be utilized to give rise to a new field: "sensory medicine."
DOI	10.1038/s42003-020-01629-2
PMID	33483561