コバヤカワ　コウ   KOBAYAKAWA KOU   小早川　高    所属   関西医科大学  附属生命医学研究所侵襲反応制御部門    職種   研究所教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice
掲載誌名	正式名：Nature communications 略　 称：Nat Commun ISSNコード：20411723
巻・号・頁	12(1),pp.2648
著者・共著者	Can Liu, Chia-Ying Lee, Greg Asher, Liqin Cao, Yuka Terakoshi, Peng Cao, Reiko Kobayakawa, Ko Kobayakawa, Katsuyasu Sakurai& Qinghua Liu
発行年月	2021/05
概要	The neural mechanisms of fear-associated thermoregulation remain unclear. Innate fear odor 2-methyl-2-thiazoline (2MT) elicits rapid hypothermia and elevated tail temperature, indicative of vasodilation-induced heat dissipation, in wild-type mice, but not in mice lacking Trpa1-the chemosensor for 2MT. Here we report that Trpa1-/- mice show diminished 2MT-evoked c-fos expression in the posterior subthalamic nucleus (PSTh), external lateral parabrachial subnucleus (PBel) and nucleus of the solitary tract (NTS). Whereas tetanus toxin light chain-mediated inactivation of NTS-projecting PSTh neurons suppress, optogenetic activation of direct PSTh-rostral NTS pathway induces hypothermia and tail vasodilation. Furthermore, selective opto-stimulation of 2MT-activated, PSTh-projecting PBel neurons by capturing activated neuronal ensembles (CANE) causes hypothermia. Conversely, chemogenetic suppression of vGlut2+ neurons in PBel or PSTh, or PSTh-projecting PBel neurons attenuates 2MT-evoked hypothermia and tail vasodilation. These studies identify PSTh as a major thermoregulatory hub that connects PBel to NTS to mediate 2MT-evoked innate fear-associated hypothermia and tail vasodilation.
DOI	10.1038/s41467-021-22914-6
PMID	33976193