ツジ　シヨウジ   TSUJI SHOJI   辻　章志    所属   関西医科大学  小児科学講座    職種   准教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	その他(不明)
表題	FcgammaRIII b and FcgammaRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy.
掲載誌名	正式名：Human immunology 略　 称：Hum Immunol ISSNコード：01988859
巻・号・頁	62(4),pp.408-413
著者・共著者	Taniuchi S, Masuda M, Yamamoto A, Hasui M, Tsuji S, Komiyama Y, Takahashi H, Kobayashi Y
発行年月	2001/04
概要	We studied 18 children with autoimmune neutropenia (AIN) to evaluate whether there was a possible relationship between the specificity of granulocyte autoantibodies (anti-NA1,2) and the phenotype of the NA system. Direct granulocyte immunofluorescence test (D-GIFT) was positive in all patients, and indirect granulocyte immunofluorescence test (I-GIFT) was positive in 17 of these 18 patients, respectively. Fourteen of 18 patients showed preferential binding to neutrophils from NA(1+2-) phenotyped donors. Immunoblotting with anti-FcRIIImAb showed that IgG prepared from 7 of 12 patients precipitated both FcRIIIb from NA1 and NA2 neutrophil lysate, whereas the other 5 precipitated only NA1. Patients' IgG did not react with purified FcRIIa. FcRIIIb genotype were NA(1+2-) in 15 of 18 patients and NA(1+2+) in the other 3. FcRIIa type of all patients were (H+R-). These distributions were significantly different from those of healthy Japanese blood donors (n = 608). The genotype of FcRIIIb and FcRIIa may affect the production of neutrophil specific auto-antibodies in AIN of infancy and influence its clinical course.
文献番号	11295474