ウエダ　ヨシヒロ   UEDA YOSHIHIRO   植田　祥啓    所属   関西医科大学  附属生命医学研究所分子遺伝学部門    職種   准教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells.
掲載誌名	正式名：Journal of Immunology 略　 称：J Immunol.
巻・号・頁	201(11),pp.1771
著者・共著者	Ueda Y, Liao D, Yang K, Patel A, Kelsoe G.
発行年月	2007/03
概要	Inflammation elicits a splenic lymphopoiesis of unknown physiologic significance but one that juxtaposes developing B cells and exogenous Ag. We show that immature and transitional 1 (immature/T1) B cells constitutively express activation-induced cytidine deaminase and B lymphocyte-induced maturation protein 1 in amounts that support accelerated plasmacytic differentiation and limited class-switch recombination. In vivo, activation of immature/T1 B cells by TLR ligands or bacterial vaccine rapidly induces T1 cells to divide, proliferate, and secrete IgM, IgG, or IgA Ab; in vitro, proliferation and differentiation are substantially enhanced by B cell-activating factor. We propose that inflammation-induced extramedullary lymphopoiesis represents a specialized mechanism for innate Ab responses to microbial pathogens.
文献番号	17339456