ウエダ　ヨシヒロ   UEDA YOSHIHIRO   植田　祥啓    所属   関西医科大学  附属生命医学研究所分子遺伝学部門    職種   准教授
論文種別	原著(症例報告除く)
言語種別
査読の有無	査読あり
表題	Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.
掲載誌名	正式名：Nature Structural & Molecular Biology 略　 称：Nat Struct Mol Biol
巻・号・頁	17(12),1492-1494
著者・共著者	Nicely NI, Dennison SM, Spicer L, Scearce RM, Kelsoe G, Ueda Y, Chen H, Liao HX, Alam SM, Haynes BF.
発行年月	2010/12
概要	The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.