ヒガサ　コウイチロウ   HIGASA KOUICHIROU   日笠　幸一郎    所属   関西医科大学  附属生命医学研究所ゲノム解析部門    職種   研究所教授
論文種別	原著(症例報告除く)
言語種別	英語
査読の有無	査読あり
表題	Population dynamics in the Japanese Archipelago since the Pleistocene revealed by the complete mitochondrial genome sequences
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：20452322
出版社	Springer Nature
巻・号・頁	11(1),pp.12018
著者・共著者	Fuzuki Mizuno, Jun Gojobori, Masahiko Kumagai, Hisao Baba, Yasuhiro Taniguchi, Osamu Kondo, Masami Matsushita, Takayuki Matsushita, Fumihiko Matsuda, Koichiro Higasa, Michiko Hayashi, Li Wang, Kunihiko Kurosaki & Shintaroh Ueda
発行年月	2021/06
概要	The Japanese Archipelago is widely covered with acidic soil made of volcanic ash, an environment which is detrimental to the preservation of ancient biomolecules. More than 10,000 Palaeolithic and Neolithic sites have been discovered nationwide, but few skeletal remains exist and preservation of DNA is poor. Despite these challenging circumstances, we succeeded in obtaining a complete mitogenome (mitochondrial genome) sequence from Palaeolithic human remains. We also obtained those of Neolithic (the hunting-gathering Jomon and the farming Yayoi cultures) remains, and over 2,000 present-day Japanese. The Palaeolithic mitogenome sequence was not found to be a direct ancestor of any of Jomon, Yayoi, and present-day Japanese people. However, it was an ancestral type of haplogroup M, a basal group of the haplogroup M. Therefore, our results indicate continuity in the maternal gene pool from the Palaeolithic to present-day Japanese. We also found that a vast increase of population size happened and has continued since the Yayoi period, characterized with paddy rice farming. It means that the cultural transition, i.e. rice agriculture, had significant impact on the demographic history of Japanese population.
DOI	10.1038/s41598-021-91357-2
PMID	34121089