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ミシマ タカオ
MISHIMA TAKAO 三島 崇生 所属 関西医科大学 腎泌尿器外科学講座 職種 講師 |
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| 論文種別 | 原著(症例報告除く) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Correlation of whole kidney hypertrophy with glomerular over-filtration in live, gender-mismatched renal transplant allografts |
| 掲載誌名 | 正式名：Nephrology 略 称：Nephrology ISSNコード：13205358/14401797 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 22(12),pp.1002-1007 |
| 著者・共著者 | Yanishi M, Tsukaguchi H, Huan N T, Koito Y, Taniguchi H, Yoshida K, Mishima T, Sugi M, Kinoshita H, Matsuda T |
| 発行年月 | 2017/12 |
| 概要 | Optimizing nephron supply to recipient demand is a non-immunologic determinant of renal allograft outcome. Nephron reduction is usually caused by physical donor-recipient mismatch, but its pathologic relevance remains to be determined.
METHODS: Thirty-one recipients of living donor renal transplants were divided into three subgroups: those who received transplants from the same gender (n = 6, Group 1) and those who underwent male-to-female (n = 8, Group 2) and female-to-male (n = 17, Group 3) transplants. Renal mass was evaluated by three-dimensional computed tomography (3D-CT) volumetry before and one year after transplantation. Glomerular volume was determined from protocol biopsies obtained one hour and one year after transplantation. RESULTS: Histologically determined glomerular volume in biopsied tissues showed a significant linear correlation with allograft size on 3D-CT volumetry (p < 0.001, r = 0.625). Mismatches in body weight, glomerular volume and kidney volume ratios were significantly greater in female-to-male (Group 3) than in male-to-female (Group 2) transplants (p < 0.001 each). Despite the two groups having nearly equal graft filtration rates one year after transplantation, proteinuria rate was three-fold higher in Group 3 than in Group 2 (p < 0.001). CONCLUSION: These findings suggest that too small graft size, frequent in female-to-male transplants, could cause hypertrophy in both kidneys and glomeruli, thereby affecting allograft function and survival. This article is protected by copyright. All rights reserved. |
| DOI | 10.1111/nep.12915 |
| 文献番号 | 27576505 |
| PMID | 27576505 |