ナカムラ　マサタカ   NAKAMURA M.   中村　正孝    所属   関西医科大学  神経内科学講座    職種   講師
言語種別	日本語
発表タイトル	レボドパ反応性でパーキンソン病様の経過をたどった進行性核上性麻痺の1剖検例
会議名	第50回日本神経病理学会総会学術研究会
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎中村聖香, 伊東秀文, 新出明代, 朝山真哉, 中村正孝, 西井誠, 木下芳美, 藤田賢吾, 朝山知子, 和手麗香, 中野智, 日下博文
発表年月日	2009/06
開催地 （都市, 国名）	高松市
概要	A Japanese man manifested bradykinesia of his left arm and leg at the age of 59, followed by propulsion and freezing of gait. He was diagnosed as Parkinson’s disease, and the symptoms were ameliorated by treatment with levodopa and dopamine receptor agonists. His motor functions were well-controlled and stable for 9 years, then bradykinesia and gait disturbance gradually deteriorated despite appropriate medications. Cognitive impairment and vertical gaze palsy developed subsequently, and he died of hepatic cell carcinoma at age 69. The fixed brain weighed 1250 grams. The globus pallidus (GP) was mildly atrophic. The discoloration of the substantia nigra (SN) was conspicuous. Microscopically, neuronal loss was marked in the subthalamic nucleus (STN), moderate in the GP and the SN, and mild in the dentate nucleus. AT8 immuno-positive neurofibrillary tangles and neuropil threads were observed in the pontine and dentate nuclei, striatum, oculomotor and trochlear nuclei, GP, SN, and STN, whereas only a few tufted astrocytes were identified. Clinicopathologically, our case is consistent with a diagnosis of “PSP-parkinsonism”.