ナカムラ カエ
NAKAMURA KAE 中村 加枝 所属 関西医科大学 生理学講座 職種 教授 |
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言語種別 | 日本語 |
発表タイトル | Reward coding by the primate dorsal raphe neurons is context dependent. |
会議名 | 第32回 日本神経科学学会 |
学会区分 | 全国規模の学会 |
発表形式 | ポスター掲示 |
講演区分 | 一般 |
発表者・共同発表者 | ◎Nakao K, Matsuzaki R, Okada O, Kobayashi Y, Nakamura K |
発表年月日 | 2009/09 |
開催地 (都市, 国名) |
名古屋 |
概要 | We have previously shown that the activity of neurons in the dorsal raphé nucleus (DRN), a major source of serotonin, is modulated by the received reward size. To study whether the DRN activity is involved in delay-based cost-benefit decision-making, we recorded single-neuronal activity in the DRN while a monkey performed a delayed-reward visually-guided saccade task. In the task, reward value (0.01 vs. 0.5ml) was indicated by the location of saccade target (right vs. left), and after saccade, a reward was delivered with a 1600ms delay. We found that about half (23/45) of DRN neurons exhibited sustained activity during the delay period 'after' saccade and before reward delivery, with either large- or small-reward preference. The same neurons often showed significantly less reward modulation if the delay (1600ms) was introduced 'before' saccade in a memory-guided saccade task. These results suggest that the coding of the size of delayed reward is dependent on the task context such as the sequence in a task. |