タカハシ　カンジ   TAKAHASHI KANJI   髙橋　寛二    所属   関西医科大学  眼科学講座    職種   非常勤講師
言語種別	英語
発表タイトル	Effects of Intravitreally Injected Bevacizumab on Vascular Endothelial Growth Factor in Fellow Eyes
会議名	European Association for Vision and Eye Research　2010
学会区分	国際学会及び海外の学会
発表者・共同発表者	◎Matsuyama K, Ogata N, Matsuoka M, Wada M, Nishimura T, Takahashi K
発表年月日	2010/10
開催地 （都市, 国名）	Creta, Greece
概要	Purpose: To determine the level of vascular endothelial growth factor (VEGF) in the fellow eyes after an intravitreal injection of bevacizumab in one eye. Methods: Eight patients who had similar findings of with proliferative diabetic retinopathy (PDR) in both eyes were studied (four patients had rubeosis, and four patients did not have rubeosis in the anterior chamber). All patients received an intravitreal injection of bevacizumab(1.25 mg) in one eye. Samples of aqueous humor were collected from the injected eyes just before and one day after the injection, and after 7 days from untreated fellow eyes. The concentration of VEGF was measured by ELISA. Results: After one day, the VEGF level in injected eyes was significantly reduced from 3230.3±2136.8 pg/ml to 3.1±3.6 pg /ml (P<0.05) in eyes with rubeosis and 465.0±78.8 pg/ml to 0 pg/ml (P<0.05) in those without rubeosis. After seven days, the VEGF levels of the fellow eyes were still significantly lower than that in the injected eyes before the injection