ナカムラ　カエ   NAKAMURA KAE   中村　加枝    所属   関西医科大学  生理学講座    職種   教授
言語種別	日本語
発表タイトル	Cognitive control of response inhibition in the primate
会議名	第34回　日本神経科学大会
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Kazuko Hayashi, Atsushi Noritake, Kae Nakamura
発表年月日	2011/09
開催地 （都市, 国名）	横浜
概要	The dorsal raphé nucleus (DRN) is a major source of serotonin. Many studies suggest that serotonergic neurotransmission is involved in emotional, cognitive and behavioral control processes. We have previously shown that the primate DRN neurons code both rewarding and aversive information during Pavlovian conditioning task. To further investigate the role of DRN in behavioral impulsivity, especially regulation of response inhibition, we used an operant conditioning procedure. In this study, a monkey (Macaca fascicularis) was trained using Go/No-go paradigm. On each trial, a fixation point appeared at the center of the screen. After the fixation, a cue was presented to the left or right of the fixation point. Each cue was associated with different action (Go/No-go). If the cue indicated "Go", the monkey made saccade to the left or right. If "No-go", the monkey had to inhibit saccade to the target and continue to gaze at the central fixation point. A liquid reward was delivered after the appropriate generation or inhibition of saccade. The monkey showed differential behavior depending on the cue and successfully learned the association of each cue with the action. The result suggests that this paradigm is useful for the electrophysiological evaluation of DRN function in regulating response inhibition. We will record single-unit activity in the DRN of monkeys performing the Go/No-go saccade task in future studies.