タカハシ　カンジ   TAKAHASHI KANJI   髙橋　寛二    所属   関西医科大学  眼科学講座    職種   非常勤講師
言語種別	英語
発表タイトル	Patient Burden Associated with Wet Age-related Macular Degeneration in Japan
会議名	ISPOR Annual Meeting 2013（International Society for Pharmacoeconomics and Outcomes Research）
学会区分	国際学会及び海外の学会
発表者・共同発表者	◎Adachi K, Wang E. C.Y, Kudo K,Crawford B, Fujita K, Nagai Y, Arisawa A, Hiramoto Y, Fujii S, Uda S. , Takahashi K, Yuzawa M
発表年月日	2013/05
開催地 （都市, 国名）	New Orleans, USA
概要	Objective Wet Age-related Macular Degeneration (wAMD) is one of the major causes of visual impairment in Japan. However the patient burden from wAMD has not been widely reported. The objective of this study was to characterize how Japanese wAMD patients are affected by the disease. Methods This is a multi-site observational study across Japan on wAMD patients who have received medical treatment during the past 12 months. Collected patient-reported outcome measures included Quality of Life using the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) and depression scale by the Geriatric Depression Scale-Short Version-Japanese (GDS-S-J). Patients also reported on treatment satisfaction, caregiver assistance, and wAMD-associated comorbidities. Results Interim data for 211 patients are reported here. 97.2% of patients were 60 years of age and over. The mean score of NEI-VFQ-25 was 68.19±17.84 and General Vision (45.78±18.07) was the lowest among 12 sub-domains. 11.4% of patients had a score of 6 or above in GDS-S-J, indicating mild depression. 38.4% and 45.5% of patients were dissatisfied with their treatment in terms on vision improvement and the time it takes for the treatment to work, respectively. 10.4% of patients needed assistance with their daily tasks, but of those, only 4.7% had a caregiver to help them day-to-day. 1.9% used paid services at home with the average of 1.3±0.47 hours per week; half of these patients used yearlong service and the rest used 6 months only. 5.9% of patients visited other doctors because of a fall which was related to their vision impairment. Conclusion Our analyses showed that 38-45% of patients were dissatisfied with their current treatment. Very few patients who required assistance were able to have a caregiver to help them day-to-day. Paid services were also barely utilized.