コバヤカワ　コウ   KOBAYAKAWA KOU   小早川　高    所属   関西医科大学  附属生命医学研究所侵襲反応制御部門    職種   研究所教授
言語種別	日本語
発表タイトル	先天的恐怖を誘発する匂い物質による生体保護作用
会議名	第43回　日本神経科学大会
主催者	日本神経科学学会
学会区分	国際学会及び海外の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	松尾 朋彦、伊早坂 智子、小早川 令子、小早川 高
発表年月日	2020/07/31
開催地 （都市, 国名）	神戸
概要	Fear is evoked when the brain perceives life-threatening danger and induces behavioral and physiological responses that increase the survival chances of individuals. However, life-preserving mechanisms conferred by innate fear remain unclear. Here, we utilized artificial innate fear odors, chemical analogs of a fox secretion, and discovered unexpected physiological and bioprotective responses in mice. Exposure to these odorants immediately induce hypothermia, bradycardia, hypometabolism, reduction of reactive oxygen species production, and increase of survival rate under lethal hypoxic condition. Furthermore, the artificial innate fear odors suppress excessive inflammatory responses and decreased mortality in lipopolysaccaride-induced sepsis model. These data suggest innate fear-inducing odors increase the odds of survival in life-threatening situations by orchestrating physiological and bioprotective responses. We also found that most of these effects are dependent on transient receptor potential ankyrin 1 (TRPA1), a receptor of innate fear odors which we had previously identified. Finally, we searched for more effective bioprotective innate fear odors and identified a chemical with highly potent anti-hypoxic activity: twenty-fold prolongation of the mean survival time in a hypoxic condition. Our artificial innate fear-inducing system would help to understand how fear contributes to survival of life, and be applicable for identifying a novel drug target for life-threatening conditions.