コバヤカワ　レイコ   KOBAYAKAWA REIKO   小早川　令子    所属   関西医科大学  附属生命医学研究所神経機能部門    職種   研究所教授
言語種別	日本語
発表タイトル	先天的恐怖を誘発する匂い物質による生体保護作用
会議名	第43回　日本神経科学大会
主催者	日本神経科学学会
学会区分	国際学会及び海外の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	松尾 朋彦、伊早坂 智子、小早川 令子、小早川 高
発表年月日	2020/07/31
開催地 （都市, 国名）	神戸
概要	Fear is evoked when the brain perceives life-threatening danger and induces behavioral and physiological responses that increase the survival chances of individuals. However, life-preserving mechanisms conferred by innate fear remain unclear. Here, we utilized artificial innate fear odors, chemical analogs of a fox secretion, and discovered unexpected physiological and bioprotective responses in mice. Exposure to these odorants immediately induce hypothermia, bradycardia, hypometabolism, reduction of reactive oxygen species production, and increase of survival rate under lethal hypoxic condition. Furthermore, the artificial innate fear odors suppress excessive inflammatory responses and decreased mortality in lipopolysaccaride-induced sepsis model. These data suggest innate fear-inducing odors increase the odds of survival in life-threatening situations by orchestrating physiological and bioprotective responses. We also found that most of these effects are dependent on transient receptor potential ankyrin 1 (TRPA1), a receptor of innate fear odors which we had previously identified. Finally, we searched for more effective bioprotective innate fear odors and identified a chemical with highly potent anti-hypoxic activity: twenty-fold prolongation of the mean survival time in a hypoxic condition. Our artificial innate fear-inducing system would help to understand how fear contributes to survival of life, and be applicable for identifying a novel drug target for life-threatening conditions.