ナガヌマ　マコト   NAGANUMA MAKOTO   長沼　誠    所属   関西医科大学  内科学第三講座    職種   教授
言語種別	英語
発表タイトル	Magnifying narrow-band imaging features of Barrett’s esophagus in relation to their Microbiome composition
会議名	第107回　日本消化器内視鏡学会総会
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎四十万谷卓也，　田原智満，　長沼誠
発表年月日	2024/05/30
国名	日本
開催地 （都市, 国名）	東京　グランドプリンスホテル新高輪　国際館パミール
開催期間	2024/05/30～2024/06/01
学会抄録	ウェブ
概要	Background/Aim: An efficient strategy for identifying patients at risk for esophageal adenocarcinoma（EAC）among patients with the Barrett’s esophagus（BE）is not well established. Our preliminary study explored mucosa associated microbiome in BE, associated with EAC risk and also investigated its association with magnifying narrow-band imaging（NBI）features of BE. Methods: Endoscopic biopsies were obtained from BE of cancer free subjects（N group: n=47）, cancerous lesions（T group: n=21）and adjacent Barrett’s esophagus（ADJ group: n=27）. Magnifying NBI features of non-neoplastic BE was classified as 1）slit/hole, and 2）vessel and 3）ridge/villous. Mucosal bacterial composition was investigated using 16s rRNA sequencing, Results: Alpha diversity was significantly lower in both T and ADJ groups compared to the N group. Relative abundance of 16 taxa such as Prevotella and Actinomyces were also changed in the same groups. The NBI feature of ridge/villous was significantly associated with lower alpha diversity in the non-neoplastic BE. Multivariate analysis demonstrated that the magnifying NBI feature was significantly elevated risks of lower alpha diversity as an independent factor. Conclusion: This is the first, reporting the potential association between change in mucosal bacterial composition and magnifying NBI features of BE that may link to EAC risk. Clinical utility of our findings needs to be further evaluated.