ヤクシジ　ユウスケ   YAKUSHIJI YUSUKE   藥師寺　祐介    所属   関西医科大学  神経内科学講座    職種   教授
言語種別	英語
発表タイトル	ASSOCIATION BETWEEN MRI MARKERS OF SMALL VESSEL DISEASE AND PROGNOSIS OF FIRST-EVER INTRACEREBRAL HEMORRHAGE
会議名	15th world stroke congress
学会区分	国際学会及び海外の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎Ikeda S, Tanaka J, Nishihara M, Ogata A, Yoshikawa M, Ide T, Suzuyama K, Yakushiji Y.
発表年月日	2023/10/10
開催地 （都市, 国名）	Toronto, Canada
開催期間	2023/10/10～2023/10/12
概要	Background and Aims Neuroimaging markers of cerebral small vessel disease (SVD) are commonly seen in stroke patients and are considered to be associated with poor prognosis after stroke. However, longitudinal studies systematically investigating associations between these representative SVD markers and clinical outcomes have been limited. The aim of this study was to determine the association between SVD burden and prognosis in patients with spontaneous intracerebral hemorrhage (sICH). Methods We recruited patients with sICH admitted to our hospital between September 2012 and August 2016. Magnetic resonance images (MRI) were rated for SVD markers, including white matter hyperintensities (WMH), periventricular hyperintensities, lacunae, perivascular spaces, and cerebral microbleeds. The clinical outcome was assessed with stroke recurrence, all-cause mortality, and motor disability using modified Rankin scale. Associations between clinical outcome and patient characteristics and the results of brain MRI were examined. Results We enrolled 219 patients with sICH. Of those, 136 were first-ever sICH. Four patients were excluded due to lack of MRI. In univariate analysis, severe WMH and total SVD score ≥3 were significantly higher mortality (3.6% vs. 15.8%, p =0.029; 50.5% vs. 87.5%, p =0.006). Severe WMH also had significantly more motor disability at 1 year. Multivariate logistic regression analysis (adjusting for age, sex, and NIHSS score) showed no significant differences between clinical outcome and the SVD markers. Conclusions This study provides insight into the SVD prognosis in sICH patients.