ナガヌマ マコト   NAGANUMA MAKOTO
  長沼 誠
   所属   関西医科大学  内科学第三講座
   職種   教授
言語種別 英語
発表タイトル Impact of endoscopic ultrasound-guided tissue acquisition on prognosis and peritoneal lavage cytology in resectable or borderline resectable pancreatic ductal adenocarcinoma.
会議名 第107回 日本消化器内視鏡学会総会
学会区分 全国規模の学会
発表形式 口頭
講演区分 一般
発表者・共同発表者◎丸尾基展, 池浦司, 長沼誠
発表年月日 2024/05/30
国名 日本
開催地
(都市, 国名)
東京 グランドプリンスホテル新高輪 国際館パミール
開催期間 2024/05/30~2024/06/01
学会抄録 ウェブ
概要 Objectives: This study aimed to evaluate the clinical impact of preoperative endoscopic ultrasound-guided tissue acquisition(EUS-TA)on prognosis and the incidence of positive peritoneal lavage cytology(PLC)during laparotomy or staging laparoscopy in patients with resectable(R)and borderline resectable(BR)PDAC.
Methods: We retrospectively collected data of the patients who were diagnosed as body and tail PDAC with/without EUS-TA at our hospital from January 2006 to December 2021.
Results: To examine the impact of EUS-TA on prognosis, 153 patients(122 patients in the EUS-TA group and 31 patients in the non-EUS-TA group)were analyzed. There was no significant difference in overall survival between the EUS-TA and non-EUS-TA groups after resection of PDAC(P = 0.777). In univariate and multivariate analysis, preoperative EUS-TA was not identified as an independent factor related to overall survival after pancreatectomy[hazard ratio 0.93, 95% confidence interval(CI)0.50-1.74, P = 0.816]. Next, to examine the direct influence of EUS-TA on the results of PLC, 114 patients(83 patients in the EUS-TA group and 31 patients in the non-EUS-TA group)were analyzed. Preoperative EUS-TA was not a statistically significant risk of positive PLC(odds ratio 0.73, 95% CI 0.25-2.20, P = 0.583).
Conclusions: EUS-TA exert no negative impact on the postoperative survival rate and PLC-positive rates in R/BR PDAC.