ナガヌマ　マコト   NAGANUMA MAKOTO   長沼　誠    所属   関西医科大学  内科学第三講座    職種   教授
言語種別	英語
発表タイトル	Impact of endoscopic ultrasound-guided tissue acquisition on prognosis and peritoneal lavage cytology in resectable or borderline resectable pancreatic ductal adenocarcinoma.
会議名	第107回　日本消化器内視鏡学会総会
学会区分	全国規模の学会
発表形式	口頭
講演区分	一般
発表者・共同発表者	◎丸尾基展，　池浦司，　長沼誠
発表年月日	2024/05/30
国名	日本
開催地 （都市, 国名）	東京　グランドプリンスホテル新高輪　国際館パミール
開催期間	2024/05/30～2024/06/01
学会抄録	ウェブ
概要	Objectives: This study aimed to evaluate the clinical impact of preoperative endoscopic ultrasound-guided tissue acquisition（EUS-TA）on prognosis and the incidence of positive peritoneal lavage cytology（PLC）during laparotomy or staging laparoscopy in patients with resectable（R）and borderline resectable（BR）PDAC. Methods: We retrospectively collected data of the patients who were diagnosed as body and tail PDAC with/without EUS-TA at our hospital from January 2006 to December 2021. Results: To examine the impact of EUS-TA on prognosis, 153 patients（122 patients in the EUS-TA group and 31 patients in the non-EUS-TA group）were analyzed. There was no significant difference in overall survival between the EUS-TA and non-EUS-TA groups after resection of PDAC（P = 0.777）. In univariate and multivariate analysis, preoperative EUS-TA was not identified as an independent factor related to overall survival after pancreatectomy［hazard ratio 0.93, 95％ confidence interval（CI）0.50-1.74, P = 0.816］. Next, to examine the direct influence of EUS-TA on the results of PLC, 114 patients（83 patients in the EUS-TA group and 31 patients in the non-EUS-TA group）were analyzed. Preoperative EUS-TA was not a statistically significant risk of positive PLC（odds ratio 0.73, 95％ CI 0.25-2.20, P = 0.583）. Conclusions: EUS-TA exert no negative impact on the postoperative survival rate and PLC-positive rates in R/BR PDAC.