ナカムラ　カエ   NAKAMURA KAE   中村　加枝    所属   関西医科大学  生理学講座    職種   教授
言語種別
発表タイトル	Neuronal modulation in appetitive and aversive contexts in the primate lateral hypothalamus
会議名	第34回　日本神経科学大会
学会区分	全国規模の学会
発表形式	ポスター掲示
発表者・共同発表者	◎Atsushi Noritake, Kae Nakamura
発表年月日	2011/09
開催地 （都市, 国名）	横浜
概要	To study how the lateral hypothalamus (LH) neurons process appetitive and/or aversive information, we recorded single-unit activity in the LH of two monkeys while they performed a Pavlovian conditioning task with two distinct contexts. In the appetitive block (APP), liquid reward or a tone was used whereas in the aversive block (AVE), an air-puff directed at the monkey face or a tone was used as unconditioned stimuli (US). In each block, there were uncued and cued trials. On the uncued trials, an US was delivered unpredictably. On the cued trials, after presentation of an alarming cue (1.2s), one of three visual conditioned stimuli (CS) associated with the outcome with probabilities of 100, 50, and 0% respectively, was presented (1.0s). A trace period (1.0s) was followed by the delivery of USs. Among 246 task-related neurons, in the APP block, many neurons' (n=48) CS response was significantly modulated by the probability of upcoming rewards (p<.01); about half (n=26) showed stronger activity for the CS associated with greater rewards whereas the other half (n=22) showed stronger activity for the CS associated with less rewards. In contrast, only a few neurons (n=9) showed modulation in the AVE block. We also found that, in the APP block, many neurons (n=39) were modulated in US activity by their predictability indicated by CSs (100%, 50%, and uncued trials); about half (n=18) responded more for predicted than unpredicted USs; the other half (n=21) responded more for unpredicted than predicted USs. In the AVE block, only eight neurons showed modulation in response to the USs depending on their predictability. These results suggest that (1) The primate LH neurons process both appetitive and aversive information; (2) However, their response is modulated by the degree of probability and/or predictability of rewards only in the appetitive context.